Usually it is enough to do it in the Web:

• we negotiate an agreement, exchanging its MS Word copies by e-mail;
• after the parties reach an agreement, they sign it, just placing their JPG signs directly into the Word document;
• the parties exchange the signed agreements by e-mail. That's all.

However, documents could be signed by hand, and they could be faxed and/or sent either by DHL, or UPS, or EMS or FedEx.